Identification of a diverse synthetic abietane diterpenoid library for anticancer activity.

ID: ALA4000202

Journal: Bioorg Med Chem Lett

Title: Identification of a diverse synthetic abietane diterpenoid library for anticancer activity.

Authors: Xu H, Liu L, Fan X, Zhang G, Li Y, Jiang B.

Abstract: A diverse natural-product-like synthetic abietane diterpenoid library contains about 56 compounds were obtained, and evaluated for their potential in vitro cytotoxic or antitumor activity against A549, PC-3 and SKOV-3 tumor cell lines by SRB assay. Treatment of A549 cells with the most potent compound ketone 19 showed induction of apoptosis, as revealed by JC-1 mitochondrial membrane potential staining, TUNNEL assay, western blotting analysis and flow cytometry assay.

CiteXplore: 28011223

DOI: 10.1016/j.bmcl.2016.12.032

Patent ID: ┄