Document Report Card
Basic Information
ID: ALA4004802
Journal: J Nat Prod
Title: α-Glucosidase Inhibitors from Malbranchea flavorosea.
Authors: Verastegui-Omaña B, Rebollar-Ramos D, Pérez-Vásquez A, Martínez AL, Madariaga-Mazón A, Flores-Bocanegra L, Mata R.
Abstract: From an extract prepared from the grain-based culture of Malbranchea flavorosea two new polyketides, namely, 8-chloroxylarinol A (1) and flavoroseoside (2), along with the known compounds xylarinol A (3), xylarinol B (4), massarigenins B and C (5 and 6), and clavatol (7), were isolated. The structures of 1 and 2 were elucidated using spectroscopic methods and corroborated by single-crystal X-ray diffraction analysis. In the case of compound 2 the absolute configuration at the stereogenic centers was established according to the method of Flack. In addition, the X-ray structure of compound 6 is reported for the first time. Compounds 3, 4, and 6 significantly inhibited yeast α-glucosidase. Compound 6 also inhibited the postprandial peak during an oral sucrose tolerance assay when tested in vivo, using normal and NA/STZ-induced hyperglycemic mice.
CiteXplore: 28060505