Document Report Card
Basic Information
ID: ALA4004811
Journal: J Nat Prod
Title: Enantiodivergence in the Biosynthesis of Bromotyrosine Alkaloids from Sponges?
Authors: Ragini K, Fromont J, Piggott AM, Karuso P.
Abstract: The isolation of bromotyrosine alkaloids, some of which are enantiomers of previously isolated compounds, has highlighted a possible enantiodivergence in their biosynthesis. Two new (1, 2) and six known bromotyrosine alkaloids (4-9), and the enantiomer (10) of a known compound, have been isolated from a Western Australian marine sponge, Pseudoceratina cf. verrucosa. The compounds inhibited the growth of multidrug-resistant and methicillin-resistant Staphylococcus aureus with comparable activity to vancomycin. In addition, one possible artifact of extraction (3) containing an ethoxy group was isolated. From analysis of the known bromotyrosine alkaloids, a biogenesis is proposed that explains the formation of antipodal natural products within this family of sponges.
CiteXplore: 28085276