Structure-based design, synthesis and antitumoral evaluation of enulosides.
Basic Information
ID: ALA4004844
Journal: Eur J Med Chem
Title: Structure-based design, synthesis and antitumoral evaluation of enulosides.
Authors: Santos JAM, Santos CS, Almeida CLA, Silva TDS, Freitas Filho JR, Militão GCG, da Silva TG, da Cruz CHB, Freitas JCR, Menezes PH.
Abstract: Enulosides, carbohydrate derivatives containing an α,β-unsaturated carbonyl unit, were designed and obtained in high yields and isomeric purity. All synthesized compounds exhibited antitumoral activity in micromolar range against four tested tumor cells lines, being the best results observed for HL-60 cells. These compounds open new possibilities to prepare an array of more active, site-specific or selective antitumor agents. 2016 Elsevier Ltd. All rights reserved.
CiteXplore: 28189083
DOI: 10.1016/j.ejmech.2017.01.036
Patent ID: ┄