Rationalized Computer-Aided Design of Matrix-Metalloprotease-Selective Prodrugs.

Basic Information

ID: ALA4014318

Journal: J Med Chem

Title: Rationalized Computer-Aided Design of Matrix-Metalloprotease-Selective Prodrugs.

Authors: Jain M, Harburn JJ, Gill JH, Loadman PM, Falconer RA, Mooney CA, Cobb SL, Berry DJ.

Abstract: Matrix metalloproteinases (MMPs) are central to cancer development and metastasis. They are highly active in the tumor environment and absent or inactive in normal tissues; therefore they represent viable targets for cancer drug discovery. In this study we evaluated in silico docking to develop MMP-subtype-selective tumor-activated prodrugs. Proof of principle for this therapeutic approach was demonstrated in vitro against an aggressive human glioma model, with involvement of MMPs confirmed using pharmacological inhibition.

CiteXplore: 28471664

DOI: 10.1021/acs.jmedchem.6b01472

Patent ID: