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ID: ALA4020772
Journal: Bioorg Med Chem Lett
Title: Alkaloids from aerial parts of Houttuynia cordata and their anti-inflammatory activity.
Authors: Ahn J, Chae HS, Chin YW, Kim J.
Abstract: New alkaloids, houttuynamide B and C (1, 2) and houttuycorine (14), were isolated from the aerial parts of Houttuynia cordata Thunb. in addition to eighteen known alkaloids. Their structures were elucidated through extensive spectroscopic analysis. All the isolates were tested for their inhibitory activity against NO production in RAW 264.7 cells stimulated by LPS. Of the tested compounds, compound 15 showed the most potent anti-inflammatory activity with an IC50 value of 8.7μM.
CiteXplore: 28499733