Fused bi-heteroaryl substituted hydantoin compounds as TACE inhibitors.

ID: ALA4020802

Journal: Bioorg Med Chem Lett

Title: Fused bi-heteroaryl substituted hydantoin compounds as TACE inhibitors.

Authors: Tong L, Kim SH, Rosner K, Yu W, Shankar BB, Chen L, Li D, Dai C, Girijavallabhan V, Popovici-Muller J, Yang L, Zhou G, Kosinski A, Siddiqui MA, Shih NY, Guo Z, Orth P, Chen S, Lundell D, Niu X, Umland S, Kozlowski JA.

Abstract: We have identified a series of hydantoin-derived TNF-a converting enzyme (TACE) inhibitors containing a pendant fused bi-heteroaryl group, which demonstrate sub-nanomolar potency (Ki), excellent activity in human whole blood assay, and improved DMPK profiles over prior series.

CiteXplore: 28558971

DOI: 10.1016/j.bmcl.2017.05.062

Patent ID: ┄