Synthesis of octapeptin C4 and biological profiling against NDM-1 and polymyxin-resistant bacteria.

ID: ALA4028839

Journal: Bioorg Med Chem Lett

Title: Synthesis of octapeptin C4 and biological profiling against NDM-1 and polymyxin-resistant bacteria.

Authors: Becker B, Butler MS, Hansford KA, Gallardo-Godoy A, Elliott AG, Huang JX, Edwards DJ, Blaskovich MAT, Cooper MA.

Abstract: The first synthesis of octapeptin C4 was achieved using a combination of solid phase synthesis and off-resin cyclisation. Octapeptin C4 displayed antibiotic activity against multi-drug resistant, NDM-1 and polymyxin-resistant Gram-negative bacteria, with moderate activity against Staphylococcus aureus. The linear analogue of octapeptin C4 was also prepared, which showed reduced activity.

CiteXplore: 28454673

DOI: 10.1016/j.bmcl.2017.04.027

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