Synthesis and biological evaluation of novel 5-aryl-4-(5-nitrofuran-2-yl)-pyrimidines as potential anti-bacterial agents.

Basic Information

ID: ALA4033695

Journal: Bioorg Med Chem Lett

Title: Synthesis and biological evaluation of novel 5-aryl-4-(5-nitrofuran-2-yl)-pyrimidines as potential anti-bacterial agents.

Authors: Verbitskiy EV, Baskakova SA, Gerasimova NA, Evstigneeva NP, Zil'berberg NV, Kungurov NV, Kravchenko MA, Skornyakov SN, Pervova MG, Rusinov GL, Chupakhin ON, Charushin VN.

Abstract: A facile two-step synthetic approach to fluorinated and non-fluorinated 5-aryl-4-(5-nitrofuran-2-yl)-pyrimidines from readily available 5-bromo-4-(furan-2-yl)pyrimidine has been developed. All synthesized compounds were screened in vitro for their antibacterial activities against twelve various bacterial strains. It is demonstrated that some of these compounds exhibited significant antibacterial activities against strains Neisseria gonorrhoeae and Staphylococcus aureus, comparable and even higher with that commercial drug Spectinomycin.

CiteXplore: 28512023

DOI: 10.1016/j.bmcl.2017.05.013

Patent ID: