Synthesis and biological evaluation of caffeic acid derivatives as potent inhibitors of α-MSH-stimulated melanogenesis.

ID: ALA4033751

Journal: Bioorg Med Chem Lett

Title: Synthesis and biological evaluation of caffeic acid derivatives as potent inhibitors of α-MSH-stimulated melanogenesis.

Authors: Jo H, Choi M, Sim J, Viji M, Li S, Lee YH, Kim Y, Seo SY, Zhou Y, Lee K, Kim WJ, Hong JT, Lee H, Jung JK.

Abstract: We have disclosed our effort to develop caffeic acid derivatives as potent and non-toxic inhibitors of α-MSH-stimulated melanogenesis to treat pigmentation disorders and skin medication including a cosmetic skin-whitening agent. The SAR studies revealed that cyclohexyl ester and secondary amide derivatives of caffeic acid showed significant inhibitory activities.

CiteXplore: 28619537

DOI: 10.1016/j.bmcl.2017.06.011

Patent ID: ┄