Importance of a 4-Alkyl Substituent for Activity in the Englerin Series.
Basic Information
ID: ALA4033770
Journal: ACS Med Chem Lett
Title: Importance of a 4-Alkyl Substituent for Activity in the Englerin Series.
Authors: Elliott DC, Beutler JA, Parker KA.
Abstract: The ring closing metathesis/transannular etherification approach to the englerin nucleus was adapted to provide two key intermediates for analogue synthesis: the 4-desmethyl Δ5,6 tricycle and the 4-oxo Δ5,6 tricycle. The former was elaborated to 4-desmethyl englerin A and the latter served as a common precursor for englerin A, 4-ethyl englerin A, and 4-isopropyl englerin A. 4-Desmethyl englerin A was less active than the natural product by an order of magnitude, but the 4-ethyl and 4-isopropyl analogues were comparable in activity to englerin A. These results are consistent with the premise that the 4-alkyl group enforces the binding conformation of the cinnamoyl ester substituent. Furthermore, they suggest that 4-alkyl englerin structures may prove to be useful tool compounds.
CiteXplore: 28740610
DOI: 10.1021/acsmedchemlett.7b00161
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