Basic Information
ID: ALA4043082
Journal: J Nat Prod
Title: Clerodane Diterpenoid Glucosides from the Stems of Tinospora sinensis.
Authors: Jiang H, Zhang GJ, Liu YF, Wang HS, Liang D.
Abstract: Ten new clerodane diterpenoid glucosides (1-10) and three known analogues (11-13) were isolated from an EtOAc extract of the stems of Tinospora sinensis. Spectroscopic analyses and chemical methods were used to elucidate the structures of these isolates. The absolute configurations of tinosinenosides A-C (1-3) were established by using experimental and calculated ECD data. Their cytotoxicity against the human epithelioid cervical carcinoma (HeLa) cell line and the nitric oxide production inhibitory activity of lipopolysaccharide-activated N9 microglial cells were tested. 1-Deacetyltinosposide A (12) exhibited mild cytotoxicity against HeLa cells, with an IC50 value of 8.35 ± 0.60 μM.
CiteXplore: 28358196
DOI: 10.1021/acs.jnatprod.6b00976
Patent ID: ┄
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