Tetrahydrobenzothiophene carboxamides: Beyond the kinase domain and into the fatty acid realm.
Basic Information
ID: ALA4043175
Journal: Bioorg Med Chem Lett
Title: Tetrahydrobenzothiophene carboxamides: Beyond the kinase domain and into the fatty acid realm.
Authors: Llona-Minguez S, Fayezi S, Alihemmati A, Juárez-Jiménez J, Piedrafita FJ, Helleday T.
Abstract: A series of tetrahydrobenzothiophene carboxamides, inspired by structural features present in kinase and SCD1 inhibitors, are presented here. Prototype compound 8 (MMDD13) modulates fatty acid elongase and desaturase indexes, lipid accumulation, while preserving kinase inhibitory activity. This chemotype represents a stepping stone towards chemical probes to study the consequences of lipid metabolism modulation through non-redundant pathways.
CiteXplore: 28807439
DOI: 10.1016/j.bmcl.2017.08.006
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