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ID: ALA4043224

Journal: Bioorg Med Chem Lett

Title: d-Amino acid mutation of PMI as potent dual peptide inhibitors of p53-MDM2/MDMX interactions.

Authors: Li X, Liu C, Chen S, Hu H, Su J, Zou Y.

Abstract: According to the previously reported potent dual l-peptide PMI of p53-MDM2/MDMX interactions, a series of d-amino acid mutational PMI analogues, PMI-1-4, with enhanced proteolytic resistence and in vitro tumor cell inhibitory activities were reported, of which Liposome-PMI-1 showed a stronger inhibitory activity against the U87 cell lines than Nutlin-3. This d-amino acid mutation strategy may give a hand for enhancing the potential of peptide drugs.

CiteXplore: 28916339

DOI: 10.1016/j.bmcl.2017.09.014