Basic Information
ID: ALA4118142
Journal: Bioorg Med Chem
Title: Novel amidrazone derivatives: Design, synthesis and activity evaluation.
Authors: Zhou H, Wang ZS, Liu XH, Chen FH.
Abstract: A series of new 6-styryl-naphthalene-2-amidrazone derivatives were synthesized and evaluated as potential ASIC1a inhibitors. Among them, compound 5e showed the most activity to inhibit [Ca2+]i. elevation in acid-induced articular chondrocytes. Together with the important role of ASIC1a in the pathogenesis of tissue acidification diseases including rheumatoid arthritis, these results might provide a meaningful hint or inspiration in developing drugs targeting at tissue acidification diseases.
CiteXplore: 29699911
DOI: 10.1016/j.bmc.2018.04.042
Patent ID: ┄
Associated Items: Associated Bioactivities Associated Assays Associated Compounds Associated Targets