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ID: ALA4118170
Journal: Bioorg Med Chem Lett
Title: Alkylsulfanyl analogs as potent α2δ ligands.
Authors: Shimada K, Ohata Y, Kobayashi J, Onishi Y, Kawamura A, Domon Y, Arakawa N, Inoue T, Kitano Y, Matsuda F, Abe Y, Deguchi T.
Abstract: We identified novel (3R, 5S)-3-aminomethyl-5-methanesulfanyl hexanoic acid (5a: DS75091588) and (3R, 5S)-3-aminomethyl-5-ethanesulfanyl hexanoic acid (6a: DS18430756) as sulfur-containing γ-amino acid derivatives that were useful for the treatment of neuropathic pain. These two compounds exhibited a potent analgesic effect in animal models of both type I diabetes and type II diabetes, and good pharmacokinetics.
CiteXplore: 29752183