The recent progress of isoxazole in medicinal chemistry.
Basic Information
ID: ALA4118235
Journal: Bioorg Med Chem
Title: The recent progress of isoxazole in medicinal chemistry.
Authors: Zhu J, Mo J, Lin HZ, Chen Y, Sun HP.
Abstract: Isoxazole compounds exhibit a wide spectrum of targets and broad biological activities. Developing compounds with heterocycle rings has been one of the trends. The integration of isoxazole ring can offer improved physical-chemical properties. Because of the unique profiles, isoxazole ring becomes a popular moiety in compounds design. In this review article, the major focus has been paid to the applications of isoxazole compounds in treating multiple diseases, including anticancer, antimicrobial, anti-inflammatory, etc. Strategies for compounds design for preclinical, clinical, and FDA approved drugs were discussed. Also, the emphasis has been addressed to the future perspectives and trend for the application.
CiteXplore: 29853341
DOI: 10.1016/j.bmc.2018.05.013
Patent ID: ┄