Discovery and evaluation of 3,5-disubstituted indole derivatives as Pim kinase inhibitors.

ID: ALA4118246

Journal: Bioorg Med Chem Lett

Title: Discovery and evaluation of 3,5-disubstituted indole derivatives as Pim kinase inhibitors.

Authors: More KN, Hong VS, Lee A, Park J, Kim S, Lee J.

Abstract: Pim kinases are promising therapeutic targets for the treatment of hematological cancers. A potent Pim kinase inhibitor 7f, derived from meridianin C, was further optimized by the replacement of 2-aminopyrimidine with substituted benzene. The optimization of the C-3 and C-5 positions of indole yielded compound 43 with improved cellular potency and high selectivity against a panel of 14 different kinases.

CiteXplore: 29871845

DOI: 10.1016/j.bmcl.2018.05.054

Patent ID: ┄