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ID: ALA4118254
Journal: Bioorg Med Chem Lett
Title: 1,2-Diphenoxiethane salts as potent antiplasmodial agents.
Authors: Schiafino-Ortega S, Baglioni E, Pérez-Moreno G, Marco PR, Marco C, González-Pacanowska D, Ruiz-Pérez LM, Carrasco-Jiménez MP, López-Cara LC.
Abstract: In this article we present a series of non-cytotoxic potent human choline kinase (CK) inhibitors that exhibit nanomolar antiplasmodial activity in vitro. The most active antiplasmodial compounds, 10a-b, bearing a pyridinium cationic head were inactive against CK, while compounds 10g and 10j with a quinolinium moiety exhibit moderate inhibition of both the parasite and the enzyme. The results point towards an additional mechanism of action unrelated to CK inhibition that remains to be established.
CiteXplore: 29880399