Document Report Card

ID: ALA4138050

Journal: Medchemcomm

Title: Discovery of selective cystathionine β-synthase inhibitors by high-throughput screening with a fluorescent thiol probe.

Authors: Niu W, Wu P, Chen F, Wang J, Shang X, Xu C.

Abstract: A high-throughput assay was developed to identify inhibitors of cystathionine β-synthase (CBS), which is one of three key enzymes involved in H₂S biosynthesis. Screening of 6491 natural compounds identified several selective CBS inhibitors, which suppressed the proliferation of HT29 cancer cells, with IC₅₀ values of less than 10 μM.

CiteXplore: 30108705

DOI: 10.1039/C6MD00493H