(Indolylalkyl)piperidine carbamates as inhibitors of fatty acid amide hydrolase (FAAH).
Basic Information
ID: ALA4138074
Journal: Medchemcomm
Title: (Indolylalkyl)piperidine carbamates as inhibitors of fatty acid amide hydrolase (FAAH).
Authors: Dahlhaus H, Hanekamp W, Lehr M.
Abstract: A series of phenyl 4-[(indol-1-yl)alkyl]piperidine carbamates was synthesized and tested for inhibition of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) and for metabolic stability in rat liver S9 fractions and porcine blood plasma. Structure-activity relationship studies revealed that variation of the length of the alkyl spacer connecting the indole and the piperidine heterocycle, introduction of substituents into the indole ring, replacement of the piperidine by a piperazine scaffold as well as opening of the piperidine ring system affect activity significantly. The metabolic stability of this compound class proved to be significantly higher than that of corresponding phenyl N-(indol-1-ylalkyl)carbamates.
CiteXplore: 30108777
DOI: 10.1039/C6MD00683C
Patent ID: ┄