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ID: ALA4177527

Journal: Bioorg Med Chem

Title: Synthesis and biological evaluation of a D-ring-contracted analogue of lamellarin D.

Authors: Colligs V, Hansen SP, Imbri D, Seo EJ, Kadioglu O, Efferth T, Opatz T.

Abstract: A D-ring contracted analogue of the strongly cytotoxic marine pyrrole alkaloid lamellarin D was synthesized and investigated for its antiproliferative action towards a wild type and a multidrug resistant (MDR) cancer cell line. The compound was found to inhibit tumor cell growth at submicromolar concentrations and showed a lower relative resistance in the MDR cell line than the antitumor drug camptothecin to which lamellarin D shows cross resistance and with which lamellarin D shares the same binding site.

CiteXplore: 28233677

DOI: 10.1016/j.bmc.2017.02.005