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ID: ALA4177651

Journal: Bioorg Med Chem Lett

Title: RNA as a small molecule druggable target.

Authors: Rizvi NF, Smith GF.

Abstract: Small molecule drugs have readily been developed against many proteins in the human proteome, but RNA has remained an elusive target for drug discovery. Increasingly, we see that RNA, and to a lesser extent DNA elements, show a persistent tertiary structure responsible for many diverse and complex cellular functions. In this digest, we have summarized recent advances in screening approaches for RNA targets and outlined the discovery of novel, drug-like small molecules against RNA targets from various classes and therapeutic areas. The link of structure, function, and small-molecule Druggability validates now for the first time that RNA can be the targets of therapeutic agents.

CiteXplore: 29097169

DOI: 10.1016/j.bmcl.2017.10.052