Identification of a diverse synthetic abietane diterpenoid library and insight into the structure-activity relationships for antibacterial activity.
Basic Information
ID: ALA4177696
Journal: Bioorg Med Chem Lett
Title: Identification of a diverse synthetic abietane diterpenoid library and insight into the structure-activity relationships for antibacterial activity.
Authors: Hou W, Zhang G, Luo Z, Li D, Ruan H, Ruan BH, Su L, Xu H.
Abstract: A diverse natural product-like (NPL) synthetic abietane diterpenoid library containing 86 compounds were obtained and the SARs were studied based on their antibacterial potential. Further in vitro cytotoxic and in silico drug-like properties evaluation showed that the potent antibacterial compound 84 had good drug-like properties and displayed low cytotoxicity toward noncancerous mammalian cells, indicating the study of AA and DHAA might be a good starting point for the search of novel antimicrobial molecules. Future work should be focused on the optimization of their potency and selectivity.
CiteXplore: 29153424
DOI: 10.1016/j.bmcl.2017.11.014
Patent ID: ┄