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ID: ALA4184172
Journal: Bioorg Med Chem Lett
Title: Isosteric ribavirin analogues: Synthesis and antiviral activities.
Authors: Zhurilo NI, Chudinov MV, Matveev AV, Smirnova OS, Konstantinova ID, Miroshnikov AI, Prutkov AN, Grebenkina LE, Pulkova NV, Shvets VI.
Abstract: The novel isosteric ribavirin analogues were synthesized by two different ways. Some of them showed significant antiviral action against hepatitis C virus (HCV), herpes simplex (HCV-1) and influenza A virus comparable to that of ribavirin itself. The data obtained confirm the proposed theory of the ribavirin possible antiviral activity mechanism related with bioisosterism.
CiteXplore: 29173944