Discovery of N-arylpyrroles as agonists of GPR120 for the treatment of type II diabetes.

ID: ALA4184291

Journal: Bioorg Med Chem Lett

Title: Discovery of N-arylpyrroles as agonists of GPR120 for the treatment of type II diabetes.

Authors: Winters MP, Sui Z, Wall M, Wang Y, Gunnet J, Leonard J, Hua H, Yan W, Suckow A, Bell A, Clapper W, Jenkinson C, Haug P, Koudriakova T, Huebert N, Murray WV.

Abstract: The discovery of a novel series of N-arylpyrroles as agonists of GPR120 (FFAR4) is discussed. One lead compound is a potent GPR120 agonist, has good selectivity for related receptor GPR40 (FFAR1), has acceptable PK properties, and is active in 2 models of Type 2 Diabetes in mice.

CiteXplore: 29456108

DOI: 10.1016/j.bmcl.2018.02.013

Patent ID: ┄