Dioxomorpholines and Derivatives from a Marine-Facultative Aspergillus Species.
Basic Information
ID: ALA4190305
Journal: J Nat Prod
Title: Dioxomorpholines and Derivatives from a Marine-Facultative Aspergillus Species.
Authors: Aparicio-Cuevas MA, Rivero-Cruz I, Sánchez-Castellanos M, Menéndez D, Raja HA, Joseph-Nathan P, González MDC, Figueroa M.
Abstract: Two new dioxomorpholines, 1 and 2, three new derivatives, 3-5, and the known compound PF1233 B (6) were isolated from a marine-facultative Aspergillus sp. MEXU 27854. Their structures were established by 1D and 2D NMR and HRESIMS data analysis. The absolute configuration of 1 and 2 was elucidated by comparison of experimental and DFT-calculated vibrational circular dichroism spectra. Compounds 3, 5, and 6 were noncytotoxic to a panel of human cancer cell lines with different functional status for the tumor-suppressor protein p53, but were inhibitors of P-glycoprotein-reversing multidrug resistance in a doxorubicin-resistant cell line.
CiteXplore: 28796494
DOI: 10.1021/acs.jnatprod.7b00331
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