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ID: ALA4196028
Journal: Eur J Med Chem
Title: Synthesis and biological evaluation of 20-epi-amino-20-deoxysalinomycin derivatives.
Authors: Li Y, Shi Q, Shao J, Yuan Y, Yang Z, Chen S, Zhou X, Wen S, Jiang ZX.
Abstract: To improve the druggability of salinomycin, a 20-epi-amino-20-deoxysalinomycin derivatives library was synthesized with high efficacy from which a few salinomycin derivatives with high potency and selectivity were identified through comprehensive cytotoxicity assay, including a fluorine-19 magnetic resonance sensitive tool molecule. Using a K-ras cellular model, salinomycin and its derivatives showed different molecular mode of action from literature reports. These results would be valuable for developing salinomycin-based cancer therapy.
CiteXplore: 29466777