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ID: ALA4219208
Journal: Bioorg Med Chem Lett
Title: 5'-Hydroxy-5'-homoaristeromycin: Synthesis and antiviral properties.
Authors: Chen Q, Liu C, Bowlin TL, Schneller SW.
Abstract: Synthetically combining the C-4' side-chain structural features of the antiviral candidates 5'-methylaristeromycin and 5'-homoaristeromycin into a diastereomeric pair of C-4' side-chain dihydroxylated aristeromycins (6 and 7) is reported. Broad antiviral analyses of the both targets found promising effects towards HBV (6, 6.7 μM and 7, 7.74 μM) and HCMV (only 7, 0.72 μM). No other activity was found. Neither of the diastereomers was cytotoxic in the assays performed.
CiteXplore: 29628328