Terpenoids isolated from Chinese liverworts Lepidozia reptans and their anti-inflammatory activity.
Basic Information
ID: ALA4219226
Journal: Bioorg Med Chem
Title: Terpenoids isolated from Chinese liverworts Lepidozia reptans and their anti-inflammatory activity.
Authors: Li S, Niu H, Qiao Y, Zhu R, Sun Y, Ren Z, Yuan H, Gao Y, Li Y, Chen W, Zhou J, Lou H.
Abstract: Five new terpenoids (1-5) including two dollabellane-type, one ent-kaurane-type diterpenoids and two sesquiterpenoids were isolated from the Chinese liverwort Lepidozia reptans (L.) Dumort., together with nine known terpenoids (6-14). Their structures were determined on the basis of analysis of MS and NMR spectroscopic data, single-crystal X-ray diffraction and electronic circular dichroism calculations. The selected compounds 1, 2, 6, 7, 9 and 14 were screened for anti-inflammatory activities by the model of LPS-induced nitric oxide (NO) production with macrophage cells, and the mechanism of the active compounds 1 and 2 were further explored.
CiteXplore: 29655613
DOI: 10.1016/j.bmc.2018.03.040
Patent ID: ┄