Biological evaluation of indolizine-chalcone hybrids as new anticancer agents.

ID: ALA4251620

Journal: Eur J Med Chem

Title: Biological evaluation of indolizine-chalcone hybrids as new anticancer agents.

Authors: Park S, Kim EH, Kim J, Kim SH, Kim I.

Abstract: A new chemical space was explored based on an indolizine-chalcone hybrid, which was readily accessible by base-mediated aldol condensation of indolizine bearing a 7-acetyl group with various (hetero)aromatic aldehydes. Their anticancer effect was evaluated, revealing that indolizine-chalcone hybrids with 3,5-dimethoxyphenyl group (4h) or the halogen at the meta position (4j and 4l) could have the potential to induce the caspase-dependent apoptosis of human lymphoma cells.

CiteXplore: 29288944

DOI: 10.1016/j.ejmech.2017.12.056

Patent ID: ┄