Penicilindoles A-C, Cytotoxic Indole Diterpenes from the Mangrove-Derived Fungus Eupenicillium sp. HJ002.
Basic Information
ID: ALA4251672
Journal: J Nat Prod
Title: Penicilindoles A-C, Cytotoxic Indole Diterpenes from the Mangrove-Derived Fungus Eupenicillium sp. HJ002.
Authors: Zheng CJ, Bai M, Zhou XM, Huang GL, Shao TM, Luo YP, Niu ZG, Niu YY, Chen GY, Han CR.
Abstract: Three new indole diterpenes, penicilindoles A-C (1-3), were isolated from the mangrove-derived fungus Eupenicillium sp. HJ002. Their planar structures and absolute configurations were determined by interpretation of NMR spectroscopic data, HR-ESIMS, and X-ray diffraction analysis using Cu Kα radiation. The cytotoxic and antibacterial activities were evaluated in vitro; penicilindole A (1) showed cytotoxic activity against human A549 and HepG2 cell lines with IC50 values of 5.5 and 1.5 μM, respectively.
CiteXplore: 29489361
DOI: 10.1021/acs.jnatprod.7b00673
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