Document Report Card

ID: ALA4257468

Journal: Medchemcomm

Title: Synthesis and biological evaluation of rapamycin-derived, next generation small molecules.

Authors: Guduru SKR, Arya P.

Abstract: Over the years, rapamycin has attracted serious attention due to its remarkable biological properties and as a potent inhibitor of the mammalian target of rapamycin (mTOR) protein through its binding with FKBP-12. Several efficient strategies that utilize synthetic and biosynthetic approaches have been utilized to develop small molecule rapamycin analogs or for synthesizing hybrid compounds containing a partial rapamycin structure to improve pharmacokinetic properties. Herein, we report selected case studies related to the synthesis of rapamycin-derived compounds and hybrid molecules to explore their biological properties.

CiteXplore: 30108899

DOI: 10.1039/C7MD00474E