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ID: ALA4257578
Journal: Bioorg Med Chem Lett
Title: 6'-Fluoro-3-deazaneplanocin: Synthesis and antiviral properties, including Ebola.
Authors: Liu C, Chen Q, Cardinale S, Bowlin TL, Schneller SW.
Abstract: A convenient stereospecific synthesis of 6'-fluoro-3-deazaneplanocin (6) has been accomplished from d-ribose in 15 steps. It is reported to possess significant activity towards Ebola (Zaire, Vero, μM: EC50 < 0.36; CC50 125; SI > 347) with moderate inhibition of the target enzyme (S-adenosylhomocysteine hydrolase), which did not correlate directly with its anti-Ebola effects. Compound 6, with limited cytotoxicity, also displayed activity against measles, H1N1 and Pichinde.
CiteXplore: 30385162