Small Molecule Mitochondrial Uncouplers and Their Therapeutic Potential.
Basic Information
ID: ALA4308823
Journal: J Med Chem
Title: Small Molecule Mitochondrial Uncouplers and Their Therapeutic Potential.
Authors: Childress ES, Alexopoulos SJ, Hoehn KL, Santos WL.
Abstract: Small molecule mitochondrial uncouplers transport protons from the mitochondrial inner membrane space into the mitochondrial matrix independent of ATP synthase, uncoupling nutrient metabolism from ATP generation. The therapeutic potential of mitochondrial uncouplers has been investigated for the treatment of metabolic diseases such as obesity and type 2 diabetes (T2D), ischemia-reperfusion injury, and neurodegenerative diseases. This communication will review the small molecule mitochondrial uncouplers reported to date and explore their potential as therapeutics.
CiteXplore: 29156129
DOI: 10.1021/acs.jmedchem.7b01182
Patent ID: ┄