Targeting tyrosine kinase: Development of acridone - pyrrole - oxindole hybrids against human breast cancer.

ID: ALA4308864

Journal: Bioorg Med Chem Lett

Title: Targeting tyrosine kinase: Development of acridone - pyrrole - oxindole hybrids against human breast cancer.

Authors: Kaur M, Singh P.

Abstract: Based on the molecular modelling studies, a rational modification of the lead molecule was made to develop highly potent compounds showing anti-cancer activity against human breast cancer cell lines MCF 7, MDA-MB-468 and T-47D. The most potent compounds have Log P and total polar surface area 4.4-5.4 and 59.8 Å, respectively and they also exhibited promising ADME profile.

CiteXplore: 30446310

DOI: 10.1016/j.bmcl.2018.11.021

Patent ID: ┄