Basic Information
ID: ALA4311934
Journal: Medchemcomm
Title: Exploration of [2 + 2 + 2] cyclotrimerisation methodology to prepare tetrahydroisoquinoline-based compounds with potential aldo-keto reductase 1C3 target affinity.
Authors: Santos ARN, Sheldrake HM, Ibrahim AIM, Danta CC, Bonanni D, Daga M, Oliaro-Bosso S, Boschi D, Lolli ML, Pors K.
Abstract: Tetrahydroisoquinoline (THIQ) is a key structural component in many biologically active molecules including natural products and synthetic pharmaceuticals. Here, we report on the use of transition-metal mediated [2 + 2 + 2] cyclotrimerisation of alkynes to generate tricyclic THIQs with potential to selectively inhibit AKR1C3.
CiteXplore: 31673310
DOI: 10.1039/C9MD00201D
Patent ID: ┄
Associated Items: Associated Bioactivities Associated Assays Associated Compounds Associated Targets