Kenalactams A-E, Polyene Macrolactams Isolated from Nocardiopsis CG3.
Basic Information
ID: ALA4316652
Journal: J Nat Prod
Title: Kenalactams A-E, Polyene Macrolactams Isolated from Nocardiopsis CG3.
Authors: Messaoudi O, Sudarman E, Bendahou M, Jansen R, Stadler M, Wink J.
Abstract: In our screening program for new biologically active secondary metabolites, a new strain, Nocardiopsis CG3 (DSM 106572), isolated from the saltpan of Kenadsa, was found to produce five new polyene macrolactams, the kenalactams A-E (1-5). Their structures were elucidated by spectral methods (NMR and HRESIMS), and the absolute configuration was derived by chemical derivatization (Mosher's method). Through a feeding experiment, alanine was proven to be the nitrogen-bearing starter unit involved in biosynthesis of the polyketide kenalactam A (1). Kenalactam E (5) was cytotoxic against human prostate cancer PC-3 cells with an IC50 value of 2.1 μM.
CiteXplore: 31021629
DOI: 10.1021/acs.jnatprod.8b00708
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