Sesquiterpenoids from the Endophytic Fungus Rhinocladiella similis.

Basic Information

ID: ALA4316655

Journal: J Nat Prod

Title: Sesquiterpenoids from the Endophytic Fungus Rhinocladiella similis.

Authors: Liu S, Zhao Y, Heering C, Janiak C, Müller WEG, Akoné SH, Liu Z, Proksch P.

Abstract: Ten new sesquiterpenoid derivatives, rhinomilisins A-J (1-10), along with six known analogues (11-16), were isolated from the mangrove-derived endophytic fungus Rhinocladiella similis. The structures of the new compounds were elucidated by their NMR and MS data, while the absolute configuration of 3 and 6 was determined by X-ray crystallographic analysis and Mosher's method, respectively. All isolated compounds (1-16) were evaluated for their cytotoxicity against the mouse lymphoma cell line L5178Y, and compounds 1, 7, and 15 showed moderate activity with IC₅₀ values of 5.0, 8.7, and 24.4 μM, respectively.

CiteXplore: 31044595

DOI: 10.1021/acs.jnatprod.8b00938

Patent ID: ┄

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