Structure-activity relationships (SAR) of triazine derivatives: Promising antimicrobial agents.
Basic Information
ID: ALA4321839
Journal: Eur J Med Chem
Title: Structure-activity relationships (SAR) of triazine derivatives: Promising antimicrobial agents.
Authors: Liu H, Long S, Rakesh KP, Zha GF.
Abstract: The emergence of drug resistance has created unmet medical need for the development of new classes of antibiotics. Innovation of new antibacterial agents with new mode of action remains a high priority universally. Triazines are six-membered, nitrogen-containing heterocyclic scaffold with a wide range of pharmaceutical properties such as antibacterial, antifungal, anticancer, antioxidants, antitubercular, antimalarial, anti-HIV, anticonvulsant, anti-inflammatory, antiulcer, and analgesic activities. The present review focuses on the recent developments in the area of medicinal chemistry to discover various chemical structures as potential antimicrobial agents and their structure-activity relationships (SAR) studies are also discussed for further rational design of this kind of derivatives.
CiteXplore: 31675510
DOI: 10.1016/j.ejmech.2019.111804
Patent ID: ┄