Synthesis and Characterization of an A6-A11 Methylene Thioacetal Human Insulin Analogue with Enhanced Stability.
Basic Information
ID: ALA4321864
Journal: J Med Chem
Title: Synthesis and Characterization of an A6-A11 Methylene Thioacetal Human Insulin Analogue with Enhanced Stability.
Authors: Zheng N, Karra P, VandenBerg MA, Kim JH, Webber MJ, Holland WL, Chou DH.
Abstract: Insulin has been a life-saving drug for millions of people with diabetes. However, several challenges exist which limit therapeutic benefits and reduce patient convenience. One key challenge is the fibrillation propensity, which necessitates refrigeration for storage. To address this limitation, we chemically synthesized and evaluated a methylene thioacetal human insulin analogue (SCS-Ins). The synthesized SCS-Ins showed enhanced serum stability and aggregation resistance while retaining bioactivity compared with native insulin.
CiteXplore: 31804076
DOI: 10.1021/acs.jmedchem.9b01589
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