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ID: ALA4325905
Journal: Eur J Med Chem
Title: Targeting PUMA/Bcl-xL interaction by new specific compounds to unleash apoptotic process in cancer cells.
Authors: Ramana Murthy AV, Narendar V, Kumar NS, Aparna P, Durga Bhavani AK, Gautier F, Barillé-Nion S, Juin P, Mosset P, Grée R, Levoin N.
Abstract: We describe the first examples of small molecules able to disrupt the nanomolar interaction between the pro-apoptotic protein PUMA and its anti-apoptotic counterpart BcL-xL in malignant cells. Based on molecular modelling studies, we propose a rationale to this result, through a new "bottle-opener"-type strategy which could be of general use in the area of protein-protein interaction studies.
CiteXplore: 30453244