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ID: ALA4330160
Journal: J Nat Prod
Title: Prenylated Indole Diterpene Alkaloids from a Mine-Soil-Derived Tolypocladium sp.
Authors: Xu LL, Hai P, Zhang SB, Xiao JF, Gao Y, Ma BJ, Fu HY, Chen YM, Yang XL.
Abstract: Ten new prenylated indole diterpene alkaloids, tolypocladin A-J (1-10), including four chlorinated metabolites, have been isolated from a culture of a mine-soil-derived fungus, Tolypocladium sp. XL115. The structures and absolute configurations of 1-10 were determined by spectroscopic analysis, ECD calculations, and comparison with known compounds. Compounds 1 and 8 displayed significant antimicrobial activities. In addition, compound 1 also showed weak cytotoxic activity against all tested human cancer cell lines and suppressed the growth and viability of the patient-derived HCC cells T1224.
CiteXplore: 30702286