Basic Information
ID: ALA4330167
Journal: J Nat Prod
Title: Chloraserrtone A, a Sesquiterpenoid Dimer from Chloranthus serratus.
Authors: Bai B, Ye SX, Yang DP, Zhu LP, Tang GH, Chen YY, Li GQ, Zhao ZM.
Abstract: Chloraserrtone A (1), a new sesquiterpenoid dimer with two lindenane-type sesquiterpenoid monomers bridged by two six-membered rings, was obtained from Chloranthus serratus. A combination of UV, IR, NMR, HRESIMS, and X-ray diffraction data were used to elucidate the structure of 1. Compound 1 represents the first lindenane-type sesquiterpenoid dimer with extremely unique C-15-C-15', C-4-C-6', and C-6-C-11' linkages to form two six-membered rings between the monomeric units. A plausible biosynthesis toward chloraserrtone A is proposed. This new compound (1), together with the known lindenane dimers (2-11), were assessed for their inhibitory effects on lipopolysaccharide-induced NO production in RAW264.7 cells. Compound 6 showed activity with an IC50 value of 3.7 μM.
CiteXplore: 30724564
DOI: 10.1021/acs.jnatprod.8b00418
Patent ID: ┄
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