Gramicidin S-inspired antimicrobial cyclodextrin to disrupt gram-negative and gram-positive bacterial membranes.

ID: ALA4334431

Journal: Medchemcomm

Title: Gramicidin S-inspired antimicrobial cyclodextrin to disrupt gram-negative and gram-positive bacterial membranes.

Authors: Yamamura H, Isshiki K, Fujita Y, Kato H, Katsu T, Masuda K, Osawa K, Miyagawa A.

Abstract: A membrane-active antimicrobial peptide gramicidin S-like amphiphilic structure was prepared from cyclodextrin. The mimic was a cyclic oligomer composed of 6-amino-modified glucose 2,3-di-O-propanoates and it exhibited antimicrobial activity against Gram-positive and Gram-negative bacteria, together with no resistance development and low haemolytic activity against red blood cells.

CiteXplore: 31803397

DOI: 10.1039/C9MD00229D

Patent ID: ┄