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ID: ALA4334532

Journal: J Nat Prod

Title: Cytotoxic p-Terphenyls from a Marine-Derived Nocardiopsis Species.

Authors: Wang D, Wang Y, Ouyang Y, Fu P, Zhu W.

Abstract: Three new p-terphenyl derivatives, nocarterphenyls A-C (1-3), along with three known analogues (4-6) were isolated from the marine-derived actinobacterial strain Nocardiopsis sp. OUCMDZ-4936. Their structures were elucidated on the basis of spectroscopic analysis and a single-crystal X-ray diffraction experiment. Compounds 1 and 2 possess a benzothiazole and benzothiazine moiety, respectively, which are rare in the skeleton of p-terphenyls. Nocarterphenyl A (1) showed potent cytotoxic activity against the HL60 and HCC1954 cancer cell lines with the IC50 values of 0.38 and 0.10 μM among 26 human cancer cell lines.

CiteXplore: 31820976

DOI: 10.1021/acs.jnatprod.9b00963