Toward Orally Absorbed Prodrugs of the Antibiotic Aztreonam. Design of Novel Prodrugs of Sulfate Containing Drugs. Part 2.

ID: ALA4334550

Journal: ACS Med Chem Lett

Title: Toward Orally Absorbed Prodrugs of the Antibiotic Aztreonam. Design of Novel Prodrugs of Sulfate Containing Drugs. Part 2.

Authors: Gordon EM, Duncton MAJ, Wang BJ, Qi L, Fan D, Li X, Ni ZJ, Ding P, Grygorash R, Low E, Yu G, Sun J.

Abstract: Aztreonam, first discovered in 1980, is an FDA approved, intravenous, monocyclic beta-lactam antibiotic. Aztreonam is active against Gram-negative bacteria and is still used today. The oral bioavailability of aztreonam in humans is less than 1%. Herein we describe the design and synthesis of potential oral prodrugs of aztreonam.

CiteXplore: 32071683

DOI: 10.1021/acsmedchemlett.9b00534

Patent ID: ┄