Synthesis and biological evaluation of solithromycin analogs against multidrug resistant pathogens.
Basic Information
ID: ALA4340531
Journal: Bioorg Med Chem Lett
Title: Synthesis and biological evaluation of solithromycin analogs against multidrug resistant pathogens.
Authors: Daher SS, Jin X, Patel J, Freundlich JS, Buttaro B, Andrade RB.
Abstract: Novel antibacterial drugs that treat multidrug resistant pathogens are in high demand. We have synthesized analogs of solithromycin using Cu(I)-mediated click chemistry. Evaluation of the analogs using Minimum Inhibitory Concentration (MIC) assays against resistant Staphylococcus aureus, Escherichia coli, and multidrug resistant pathogens Enterococcus faecium and Acinetobacter baumannii showed they possess potencies similar to those of solithromycin, thus demonstrating their potential as future therapeutics to combat the existential threat of multidrug resistant pathogens.
CiteXplore: 30962084
DOI: 10.1016/j.bmcl.2019.03.038
Patent ID: ┄