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ID: ALA4342407

Journal: Bioorg Med Chem

Title: Thieno[2,3-d]pyrimidine as a promising scaffold in medicinal chemistry: Recent advances.

Authors: Ali EMH, Abdel-Maksoud MS, Oh CH.

Abstract: Thienopyrimidine scaffold is a fused heterocyclic ring system that structurally can be considered as adenine, the purine base that is found in both DNA and RNA-bioisosteres. Thienopyrimidines exist in three distinct isomeric forms. The current review discusses thieno[2,3-d]pyrimidine as a one of the opulent heterocycles in drug discovery. Its broad range of medical applications such as anticancer, anti-inflammatory, anti-microbial, and CNS protective agents has inspired us to study its structure-activity relationship (SAR), along with its relevant synthetic strategies. The present review briefly summarizes synthetic approaches for the preparation of thieno[2,3-d]pyrimidine derivatives. In addition, the promising biological activities of this scaffold are also illustrated with explanatory diagrams for their SAR studies.

CiteXplore: 30826188

DOI: 10.1016/j.bmc.2019.02.044