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ID: ALA4342425
Journal: Bioorg Med Chem Lett
Title: Synthesis and antitumor activity of bis(arylsulfonyl)dihydroimidazolinone derivatives.
Authors: Sittihan S, Jumpathong W, Sopha P, Ruchirawat S.
Abstract: A series of novel bis(arylsulfonyl)dihydroimidazolinones with different aryl substitution patterns were readily synthesized and evaluated for their antitumor activities. Some of the newly synthesized compounds exhibited cytotoxicity at micromolar range against multiple cancer cell lines, including A549, HepG2, HuCCA-1, and MOLT-3. The most potent analogue contained pentafluorobenzenesulfonyl groups, which could be chemically elaborated to serve as a potential pharmacophore.
CiteXplore: 31704206